At a young age and under a grant from the Canada Council for the Arts, Nathalie Breuer left to study at the Maurice Béjart School. During two and a half years, she studied in an intensive dance and theatre program. Later on, her choice was naturally to become an actress. She did an internship at the Théâtre de l'Atelier in Paris and then another in Montreal at the Théâtre de la Veillée, guided by Warren Robertson for many years.

Since then, she has worked in both French and English for multiple theatres, television and film productions. She also lends her voice to numerous advertising campaigns. 

Over the years, Nathalie has portrayed characters such as Anne Daviau for seven years in Providence, Suzanne Brosseau in Les invincibles, and Céline in the U.S./Canadian co-production Being Human, to name just a few. More recently, she appeared in Les beaux malaises, District 31, Après, Les moments parfaits, and Un gars une fille 2.0. She also has a recurring role in the series Temps de chien, in which she plays Manon, a rather surprising character.

Since its creation, she has participated in Poésie, sandwichs et autres soirs qui penchent, directed by Loui Mauffette, a show with as huge a success in Montreal as in France. She also played Lady Montaigu in the impressive cast of Roméo & Juliette at TNM (m.e.s Serge Denoncourt). She also graces the stage of the Théâtre d'Aujourd'hui in Chansons pour filles et garçons perdus.

For the last couple years, she has also participated in several web series such as 11 règles (Yan Turgeon), Fabrique-moi un conte (Jean-François Rivard), Réso...etc.