Charlotte Le Bon is a multidisciplinary artist who shines both in Quebec and internationally. She made a remarkable television debut in 2010, bringing her unique touch of comedy to Le Grand Journal (Canal+). Her role as Claire in La Marche by Nabil Ben Yadir earned her a nomination at the prestigious Césars for Revelation of the Year in 2013. The following year, she charmed audiences as Anna in Benjamin Guedj's Libre et Assoupi, then portrayed Victoire Doutreleau in Yves Saint Laurent by Jalil Lespert, a performance that earned her a second Césars nomination for Best Supporting Actress. She then began a career in the United States, working with directors such as Lasse Hallström, Robert Zemeckis, and Sean Ellis.

On television, she starred in the French series Cheyenne & Lola in 2020, before captivating Quebec audiences in C’est comme ça que je t’aime (2022–2024), acclaimed for its unique tone and 1970s aesthetic.

Also a visual artist, Charlotte explores the strange through painting, drawing, and lithography. A fan of genre cinema, she wrote and directed her first short film, Judith Hôtel, presented at Cannes in 2018. In 2022, she wrote and directed her first feature film, Falcon Lake, which was selected for the Director's Fortnight at the 75th Cannes Film Festival. Upon its release, the film received universal acclaim and won several awards, including the Louis-Delluc Prize, the John Dunning Prize, as well as a Césars nomination for Best First Film.

She recently portrayed Niki in the biopic of French artist Niki de Saint Phalle, directed by Céline Sallette and released in 2024. In 2025, Charlotte joined the cast of the highly popular HBO series The White Lotus, confirming her place in major international productions.