A graduate in Acting in 2003, Mélanie launched a distinguished career in film, theatre, and television. She first gained widespread recognition for her role in the romantic comedy Les Ex, and went on to portray a wide range of memorable characters in series such as Alertes, Comme des têtes pas de poule, Plan B, Chaos, Discussions avec mes parents, Unité 9, Mémoires vives, Les Pays d’en haut, and Toute la vérité.

On stage, she notably stood out in Cygnes Noirs at Théâtre Prospero and in Et je sais que cela doit être le paradis at La Licorne. She also performed in Les peintres du charbon at Théâtre Duceppe and in Merci Chéri at the St-Sauveur summer theatre. She delivered a memorable portrayal of Roxane in Cyrano de Bergerac, directed by Michèle Deslauriers.

In cinema, she has appeared in La Petite Reine by Alexis Durand-Brault and Nuits by Renée Beaulieu. Alongside her acting career, she has been teaching on-camera acting to professional actors at the school she founded in 2015, Ateliers Mélanie Pilon. After completing directing training at INIS in 2020, she has directed several award-winning short films presented at festivals around the world, including Mission Cohésion, Digne, Piégé, and Assises, further affirming her talent and versatility within the audiovisual landscape.